Biology:Area composita
From HandWiki
Short description: Main component of the mammalian cardiac intercalated discs
The area composita is a special heart muscle specific mixed type adhering junction connecting single cardiomyocytes. They are responsible for the force transmission during muscle contraction and are believed to be the main component of the mammalian cardiac intercalated discs.[1][2][3][4] Area composita structures consist of typical desmosomal in addition to typical fascia adhaerens proteins, whereas in epithelia both molecular classes show distinct and mutual exclusive localizations and both structures are also well separated.
References
- ↑ Franke, Werner W.; Borrmann, Carola M.; Grund, Christine; Pieperhoff, Sebastian (2006). "The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins". European Journal of Cell Biology 85 (2): 69–82. doi:10.1016/j.ejcb.2005.11.003. PMID 16406610.
- ↑ Pieperhoff, Sebastian; Franke, Werner W. (2007). "The area composita of adhering junctions connecting heart muscle cells of vertebrates – IV: Coalescence and amalgamation of desmosomal and adhaerens junction components – Late processes in mammalian heart development". European Journal of Cell Biology 86 (7): 377–391. doi:10.1016/j.ejcb.2007.04.001. PMID 17532539.
- ↑ Pieperhoff, Sebastian; Franke, Werner W. (2008). "The area composita of adhering junctions connecting heart muscle cells of vertebrates". European Journal of Cell Biology 87 (7): 413–430. doi:10.1016/j.ejcb.2008.02.005. PMID 18420304.
- ↑ Goossens, S.; Janssens, B.; Bonne, S.; De Rycke, R.; Braet, F.; Van Hengel, J.; Van Roy, F. (2007). "A unique and specific interaction between T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs". Journal of Cell Science 120 (12): 2126–2136. doi:10.1242/jcs.004713. PMID 17535849.
- Borrmann, Carola M.; Grund, Christine; Kuhn, Cäcilia; Hofmann, Ilse; Pieperhoff, Sebastian; Franke, Werner W. (2006). "The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk". European Journal of Cell Biology 85 (6): 469–485. doi:10.1016/j.ejcb.2006.02.009. PMID 16600422.
- Waschke, Jens (2008). "The desmosome and pemphigus". Histochemistry and Cell Biology 130: 21–54. doi:10.1007/s00418-008-0420-0. PMID 18386043.
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