Biology:Attractin
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Attractin is a protein that in humans is encoded by the ATRN gene.[1][2][3]
Attractin is a Group XI C-type lectin.
Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.[3]
References
- ↑ "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions". Proc Natl Acad Sci U S A 95 (19): 11336–41. Oct 1998. doi:10.1073/pnas.95.19.11336. PMID 9736737. Bibcode: 1998PNAS...9511336D.
- ↑ "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells". J Immunol 156 (5): 1714–21. Apr 1996. PMID 8596018.
- ↑ 3.0 3.1 "Entrez Gene: ATRN attractin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8455.
External links
- Human ATRN genome location and ATRN gene details page in the UCSC Genome Browser.
Further reading
- "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon Ganka Gakkai Zasshi 96 (11): 1418–22. 1993. PMID 1476071.
- Nagase T; Ishikawa K; Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
- Nagle DL; McGrail SH; Vitale J et al. (1999). "The mahogany protein is a receptor involved in suppression of obesity". Nature 398 (6723): 148–52. doi:10.1038/18210. PMID 10086355. Bibcode: 1999Natur.398..148N.
- Gunn TM; Miller KA; He L et al. (1999). "The mouse mahogany locus encodes a transmembrane form of human attractin". Nature 398 (6723): 152–6. doi:10.1038/18217. PMID 10086356. Bibcode: 1999Natur.398..152G.
- Tang W; Gunn TM; McLaughlin DF et al. (2000). "Secreted and membrane attractin result from alternative splicing of the human ATRN gene". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6025–30. doi:10.1073/pnas.110139897. PMID 10811918. Bibcode: 2000PNAS...97.6025T.
- Deloukas P; Matthews LH; Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Gevaert K; Goethals M; Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- "Isolation and characterization of attractin-2". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 524: 109–13. 2003. doi:10.1007/0-306-47920-6_14. ISBN 0-306-47717-3. PMID 12675230.
- "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics 4 (2): 454–65. 2004. doi:10.1002/pmic.200300556. PMID 14760718.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Liu T; Qian WJ; Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
- Wrenger S; Faust J; Friedrich D et al. (2007). "Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function". J. Leukoc. Biol. 80 (3): 621–9. doi:10.1189/jlb.1105678. PMID 16835316.
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