Biology:Autophagic cell death
From HandWiki
Autophagic cell death (ACD) is a controversial form of programmed cell death that is morphologically distinct from apoptosis and necrosis.[1][2] While autophagy is generally considered a cellular survival mechanism, ACD occurs when excessive or dysregulated autophagy leads to the cell's demise.[3] This type of cell death is characterized by the large-scale accumulation of autophagosomes, giving the cell a vacuolated appearance.[1] However, the exact mechanisms and circumstances under which autophagy transitions from a protective process to a lethal one remain subjects of ongoing debate.[4]
References
- ↑ 1.0 1.1 "Autophagic cell death: the story of a misnomer". Nature Reviews. Molecular Cell Biology 9 (12): 1004–10. December 2008. doi:10.1038/nrm2529. PMID 18971948.
- ↑ "Autophagic cell death". Methods in Enzymology 453: 17–31. 2009. doi:10.1016/S0076-6879(08)04002-0. PMID 19216900.
- ↑ "Autophagy: Regulator of cell death". Cell Death & Disease 14 (10): 648. October 2023. doi:10.1038/s41419-023-06154-8. PMID 37794028.
- ↑ "Cell death by autophagy: facts and apparent artefacts". Cell Death and Differentiation 19 (1): 87–95. January 2012. doi:10.1038/cdd.2011.146. PMID 22052193.
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