Biology:BMF (gene)
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Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.[1][2]
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]
Interactions
BMF (gene) has been shown to interact with Bcl-2[1] and DYNLL2.[1][3]
References
- ↑ 1.0 1.1 1.2 "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science 293 (5536): 1829–32. Sep 2001. doi:10.1126/science.1062257. PMID 11546872. Bibcode: 2001Sci...293.1829P.
- ↑ 2.0 2.1 "Entrez Gene: BMF Bcl2 modifying factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90427.
- ↑ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (Feb 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMID 14561217.
Further reading
- "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. 2001. doi:10.1093/dnares/7.6.357. PMID 11214971.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2432–7. 2003. doi:10.1073/pnas.0438011100. PMID 12591950. Bibcode: 2003PNAS..100.2432L.
- "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.". Biochem. J. 377 (Pt 3): 597–605. 2004. doi:10.1042/BJ20031251. PMID 14561217.
- "Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells.". Leukemia 18 (1): 41–7. 2004. doi:10.1038/sj.leu.2403183. PMID 14574334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. 2005. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
- "BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.". Mol. Cell 17 (4): 525–35. 2005. doi:10.1016/j.molcel.2005.02.003. PMID 15721256.
- "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.". Pathology 38 (1): 33–4. 2006. doi:10.1080/00313020500455811. PMID 16484005.
- "Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation.". Apoptosis 11 (8): 1349–57. 2007. doi:10.1007/s10495-006-8266-1. PMID 16830229.
- "Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3787–92. 2007. doi:10.1073/pnas.0700115104. PMID 17360431. Bibcode: 2007PNAS..104.3787S.
- "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.". Tumori 93 (2): 195–7. 2007. doi:10.1177/030089160709300214. PMID 17557568.
External links
- Human BMF genome location and BMF gene details page in the UCSC Genome Browser.
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