Biology:C1orf38

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene.[1] The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712.[1] C1orf38 has been associated with cancer susceptibility.[2]

References

  1. 1.0 1.1 "Chromosome 1 open reading frame 38". https://www.ncbi.nlm.nih.gov/gene/9473. 
  2. Springwald, A.; Lattrich, C.; Seitz, S.; Ortmann, O.; Treeck, O. (2009). "Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility". Cancer Investigation 27 (6): 669–672. doi:10.1080/07357900802620877. PMID 19308812. 

Further reading

  • Treeck, O.; Springwald, A.; Konwisorz, A.; Lattrich, C.; Goerse, R.; Ortmann, O.; Treeck, O. (2011). "Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine 28 (1): 121–127. doi:10.3892/ijmm.2011.663. PMID 21455565. 
  • Springwald, A.; Lattrich, C.; Skrzypczak, M.; Goerse, R.; Ortmann, O.; Treeck, O. (2010). "Icb-1Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated with HER2 Expression". Cancer Investigation 28 (9): 904–909. doi:10.3109/07357907.2010.483511. PMID 20569072. 
  • Konwisorz, A.; Springwald, A.; Haselberger, M.; Goerse, R.; Ortmann, O.; Treeck, O. (2009). "Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells". Endocrine-Related Cancer 17 (1): 147–157. doi:10.1677/ERC-09-0095. PMID 19942713.