Biology:CAMSAP3
From HandWiki
Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.
Function
CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.[1]
In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.[2] This gives the epithelial cells their rectangular shape.
In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.[3]
References
- ↑ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins" (in en). Molecular Biology and Evolution 26 (9): 2005–2014. doi:10.1093/molbev/msp115. ISSN 0737-4038. PMID 19508979. https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msp115.
- ↑ "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America 113 (2): 332–337. January 2016. doi:10.1073/pnas.1520638113. PMID 26715742. Bibcode: 2016PNAS..113..332T.
- ↑ "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science 357 (6354): 925–928. September 2017. doi:10.1126/science.aam9335. PMID 28860385. Bibcode: 2017Sci...357..925Z.
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