Biology:CD96

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene. CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1). The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.

Function

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

Further reading

• "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)". Journal of Immunology 172 (7): 3994–3998. April 2004. doi:10.4049/jimmunol.172.7.3994. PMID 15034010. 
• "CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America 104 (26): 11008–11013. June 2007. doi:10.1073/pnas.0704271104. PMID 17576927. Bibcode: 2007PNAS..10411008H. 
• "Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome". American Journal of Human Genetics 81 (4): 835–841. October 2007. doi:10.1086/522014. PMID 17847009. 
• "CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains". The Journal of Biological Chemistry 284 (4): 2235–2244. January 2009. doi:10.1074/jbc.M807698200. PMID 19056733. 
• "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity 11 (3): 232–238. April 2010. doi:10.1038/gene.2010.1. PMID 20237496. 
• "[CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia]" (in zh). Zhongguo Shi Yan Xue Ye Xue Za Zhi 19 (3): 585–588. June 2011. PMID 21729528. 
• "Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96". PLOS ONE 7 (8): e42426. 2012. doi:10.1371/journal.pone.0042426. PMID 22879978. Bibcode: 2012PLoSO...742426M. 
• "Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection". PLOS ONE 7 (12): e51696. 2012. doi:10.1371/journal.pone.0051696. PMID 23272144. Bibcode: 2012PLoSO...751696E. 
• "Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia". Archives of Medical Research 45 (4): 343–350. May 2014. doi:10.1016/j.arcmed.2014.04.001. PMID 24751333. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.