Biology:CEMIP
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Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.[1] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.[2] Such function has been also been validated in mice.[3]
CEMIP is associated with nonsyndromic deafness,[4] as well as a variety of cancers.[5]
References
- ↑ "Entrez Gene: KIAA1199 KIAA1199". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57214.
- ↑ Yoshida, H.; Nagaoka, A.; Kusaka-Kikushima, A.; Tobiishi, M.; Kawabata, K.; Sayo, T.; Sakai, S.; Sugiyama, Y. et al. (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences 110 (14): 5612–5617. doi:10.1073/pnas.1215432110. PMID 23509262. Bibcode: 2013PNAS..110.5612Y.
- ↑ Yoshida, Hiroyuki; Nagaoka, Aya; Nakamura, Sachiko; Sugiyama, Yoshinori; Okada, Yasunori; Inoue, Shintaro (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMID 24251095.
- ↑ "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet 48 (11): 564–70. Nov 2003. doi:10.1007/s10038-003-0079-2. PMID 14577002.
- ↑ Zhang, Yongsheng; Jia, Shuqin; Jiang, Wen (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports 31 (4): 1503–1508. doi:10.3892/or.2014.3038. PMID 24573670.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. 2000. doi:10.1093/dnares/6.5.337. PMID 10574462.
- "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.". Genomics 72 (1): 88–98. 2001. doi:10.1006/geno.2000.6466. PMID 11247670.
- "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. 2003. doi:10.1101/gr.406902. PMID 12421765.
- "Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues". Am. J. Hum. Genet. 72 (1): 73–82. 2003. doi:10.1086/345398. PMID 12471561.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Lett. 580 (2): 581–4. 2006. doi:10.1016/j.febslet.2005.12.076. PMID 16406369.
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