Biology:CEP120

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.

Function

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.

External links

• Human CEP120 genome location and CEP120 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 120 kDa (CEP120)

Further reading

• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data". JAMA 302 (2): 168–78. 2009. doi:10.1001/jama.2009.978-a. PMID 19584346. 
• "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration". Neuron 56 (1): 1–3. 2007. doi:10.1016/j.neuron.2007.09.019. PMID 17920006. 
• "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. 2009. doi:10.1038/ng.274. PMID 19079260.