Biology:CEP350

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

External links

• Human CEP350 genome location and CEP350 gene details page in the UCSC Genome Browser.

Further reading

• "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. 1998. doi:10.1093/dnares/4.5.345. PMID 9455484. 
• "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene 284 (1–2): 203–13. 2002. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. 2003. doi:10.1038/nature02166. PMID 14654843. Bibcode: 2003Natur.426..570A. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N. 
• "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex". J. Cell Sci. 120 (Pt 18): 3299–308. 2007. doi:10.1242/jcs.013102. PMID 17878239.