Biology:CFHR5
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Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene.[1][2][3]
Function
CFHR5 is structurally related to complement factor H which plays an important role in the regulation of a branch of the innate immune system called the alternative complement pathway. Like complement factor H, CFHR5 is able to bind to complement C3.[4]
Clinical Significance
A mutation in CHFR5 was found in patients with the disease CFHR5 nephropathy, which is a common cause of renal disease in Cyprus. The mutated form of the protein found in patients with this disease has impaired ability to bind to complement C3, suggesting that CFHR5 is important in protecting the kidneys from attack by the complement system.[5]
References
- ↑ "Human factor H-related protein 5 (FHR-5). A new complement-associated protein". J Biol Chem 276 (9): 6747–54. Mar 2001. doi:10.1074/jbc.M007495200. PMID 11058592.
- ↑ "Location and structure of the human FHR-5 gene". Genetica 114 (2): 157–61. Jun 2002. doi:10.1023/A:1015114512924. PMID 12041828.
- ↑ "Entrez Gene: CFHR5 complement factor H-related 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81494.
- ↑ "Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein.". J. Immunol. 174 (10): 6250–6. 2005. doi:10.4049/jimmunol.174.10.6250. PMID 15879123.
- ↑ "Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis". Lancet 376 (9743): 794–801. September 2010. doi:10.1016/S0140-6736(10)60670-8. PMID 20800271.
External links
- GeneReviews/NCBI/NIH/UW entry on Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II
- Human CFHR5 genome location and CFHR5 gene details page in the UCSC Genome Browser.
Further reading
- "Complement-regulator factor H and related proteins in otitis media with effusion.". Clin. Immunol. 100 (1): 118–26. 2001. doi:10.1006/clim.2001.5043. PMID 11414752.
- "Factor H-related protein-5: a novel component of human glomerular immune deposits.". Am. J. Kidney Dis. 39 (1): 24–7. 2002. doi:10.1053/ajkd.2002.29873. PMID 11774097.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein.". J. Immunol. 174 (10): 6250–6. 2005. doi:10.4049/jimmunol.174.10.6250. PMID 15879123.
- "Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).". J. Med. Genet. 43 (7): 582–9. 2006. doi:10.1136/jmg.2005.038315. PMID 16299065.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome.". Mol. Immunol. 44 (7): 1704–8. 2007. doi:10.1016/j.molimm.2006.08.004. PMID 17000000.
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