Biology:CHMP5
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.[1][2][3]
Function
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.[3][4]
References
- ↑ "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem 280 (11): 10548–55. Mar 2005. doi:10.1074/jbc.M413734200. PMID 15644320.
- ↑ "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci 114 (Pt 13): 2395–404. Sep 2001. doi:10.1242/jcs.114.13.2395. PMID 11559748.
- ↑ 3.0 3.1 "Entrez Gene: CHMP5 chromatin modifying protein 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51510.
- ↑ "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics 88 (3): 333–46. September 2006. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
External links
- Human CHMP5 genome location and CHMP5 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell 114 (6): 689–99. 2003. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
- "The protein network of HIV budding". Cell 114 (6): 701–13. 2003. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
- "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. 2003. doi:10.1073/pnas.2133846100. PMID 14519844. Bibcode: 2003PNAS..10012414M.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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