Biology:CKS2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.[1][2][3]
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.[3]
References
- ↑ "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe". Genes Dev 4 (8): 1332–44. Dec 1990. doi:10.1101/gad.4.8.1332. PMID 2227411.
- ↑ "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet 73 (3): 250–4. Sep 1996. doi:10.1159/000134349. PMID 8697818.
- ↑ 3.0 3.1 "Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1164.
External links
- Human CKS2 genome location and CKS2 gene details page in the UCSC Genome Browser.
Further reading
- "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.". Science 262 (5132): 387–95. 1993. doi:10.1126/science.8211159. PMID 8211159. Bibcode: 1993Sci...262..387P.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.". J. Biol. Chem. 280 (3): 2092–104. 2005. doi:10.1074/jbc.M403080200. PMID 15504738.
- "Mutual inhibition of separase and Cdk1 by two-step complex formation.". Mol. Cell 19 (1): 135–41. 2005. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.
- "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.". FEBS Lett. 581 (6): 1166–72. 2007. doi:10.1016/j.febslet.2007.02.028. PMID 17336302.
- "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.". PLOS Med. 4 (3): e90. 2007. doi:10.1371/journal.pmed.0040090. PMID 17388661.
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