Biology:CLDN2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[1][2] It belongs to the group of claudins.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][2]
Function
Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[3] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[4] Furthermore, claudin-2 has been shown to form paracellular channels for water.[5]
References
- ↑ "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A 96 (2): 511–6. March 1999. doi:10.1073/pnas.96.2.511. PMID 9892664. Bibcode: 1999PNAS...96..511M.
- ↑ 2.0 2.1 "Entrez Gene: CLDN2 claudin 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075.
- ↑ Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H. et al. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences 107 (17): 8011–8016. doi:10.1073/pnas.0912901107. PMID 20385797. Bibcode: 2010PNAS..107.8011M.
- ↑ Amasheh, S; Meiri, N; Gitter, A. H.; Schöneberg, T; Mankertz, J; Schulzke, J. D.; Fromm, M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID 12432083.
- ↑ Rosenthal, R.; Milatz, S.; Krug, S. M.; Oelrich, B.; Schulzke, J. -D.; Amasheh, S.; Gunzel, D.; Fromm, M. (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438.
External links
- Human CLDN2 genome location and CLDN2 gene details page in the UCSC Genome Browser.
Further reading
- "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. 2000. doi:10.1023/A:1006995910836. PMID 10690502.
- "The roles of claudin superfamily proteins in paracellular transport". Traffic 2 (2): 93–8. 2001. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
- "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. 2001. doi:10.1038/35067088. PMID 11283726.
- "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. 2003. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
- "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. 2003. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
- "Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin". J. Cell Biol. 141 (7): 1539–50. 1998. doi:10.1083/jcb.141.7.1539. PMID 9647647.
- "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. 2000. doi:10.1083/jcb.147.6.1351. PMID 10601346.
- "Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha". J. Biol. Chem. 277 (24): 21361–70. 2002. doi:10.1074/jbc.M110261200. PMID 11934881.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture". Am. J. Physiol., Cell Physiol. 284 (6): C1346–54. 2003. doi:10.1152/ajpcell.00547.2002. PMID 12700140.
- "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity". Biochem. Biophys. Res. Commun. 314 (4): 1001–7. 2004. doi:10.1016/j.bbrc.2003.12.185. PMID 14751232.
- "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690–4. 2004. doi:10.1073/pnas.0306924101. PMID 15070779. Bibcode: 2004PNAS..101.4690Y.
- "Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells". J. Cell. Physiol. 203 (1): 15–26. 2005. doi:10.1002/jcp.20189. PMID 15389642.
- "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res 15 (2): 339–359. 2015. doi:10.1021/acs.jproteome.5b00769. PMID 26680015. PMC 4777318. https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01.
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