Biology:CNOT6
From HandWiki
 Generic protein structure example |
CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.[1][2]
The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.[2]
References
- ↑ "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase". EMBO J 21 (6): 1414–26. Mar 2002. doi:10.1093/emboj/21.6.1414. PMID 11889047.
- ↑ 2.0 2.1 "Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57472.
External links
- Human CCR4 genome location and CCR4 gene details page in the UCSC Genome Browser.
- Human CNOT6 genome location and CNOT6 gene details page in the UCSC Genome Browser.
Further reading
- "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles.". Genomics 30 (2): 178–86. 1996. doi:10.1006/geno.1995.9887. PMID 8586417.
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. 2000. doi:10.1093/dnares/6.5.337. PMID 10574462.
- "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.". Nucleic Acids Res. 28 (3): 809–17. 2000. doi:10.1093/nar/28.3.809. PMID 10637334.
- "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.". BMC Genomics 2: 9. 2003. doi:10.1186/1471-2164-2-9. PMID 11747467.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.". Genes Dev. 18 (16): 2010–23. 2004. doi:10.1101/gad.1219104. PMID 15314026.
- "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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