Biology:COG4
 Generic protein structure example |
Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.[1][2]
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM][2]
Interactions
COG4 has been shown to interact with COG7,[3] COG2,[3] COG1[3] and COG5.[3]
Clinical
Mutations in this gene have been associated with Saul-Wilson syndrome.[4]
References
- ↑ "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol 157 (3): 405–15. Apr 2002. doi:10.1083/jcb.200202016. PMID 11980916.
- ↑ 2.0 2.1 "Entrez Gene: COG4 component of oligomeric golgi complex 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25839.
- ↑ 3.0 3.1 3.2 3.3 Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
- ↑ Ferreira C (2020) Saul-Wilson syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. SourceGeneReviews. Seattle (WA): University of Washington, Seattle
Further reading
- "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.". Dev. Cell 1 (4): 527–37. 2001. doi:10.1016/S1534-5807(01)00063-6. PMID 11703943.
- "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. 2002. doi:10.1074/jbc.M202326200. PMID 11929878.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. 2004. doi:10.1074/jbc.M400662200. PMID 15047703.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
- Human COG4 genome location and COG4 gene details page in the UCSC Genome Browser.
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