Biology:CYREN (protein)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
Cell cycle regulator of non-homologous end joining is a protein that in humans is encoded by the CYREN gene.
It prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks.[1] This protein is therefore important in regulating DNA repair.
When alternatively spliced, is predicted to produce three different micropeptides.[2]
- MRI-1 was previously found to be a modulator of retrovirus infection.[2]
- MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway.[2]
- MRI-3
References
- ↑ "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature 549 (7673): 548–552. September 2017. doi:10.1038/nature24023. PMID 28959974. Bibcode: 2017Natur.549..548A.
- ↑ 2.0 2.1 2.2 "A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining". The Journal of Biological Chemistry 289 (16): 10950–7. April 2014. doi:10.1074/jbc.c113.533968. PMID 24610814.
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