Biology:Calcium-binding mitochondrial carrier protein SCaMC-1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution". The Journal of Biological Chemistry 279 (29): 30722–30. July 2004. doi:10.1074/jbc.M400445200. PMID 15123600. 
• "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry 279 (23): 24701–13. June 2004. doi:10.1074/jbc.M401417200. PMID 15054102. 
• "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation 19 (4): 650–60. April 2012. doi:10.1038/cdd.2011.139. PMID 22015608. 
• "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine 34 (2–3): 465–84. 2013. doi:10.1016/j.mam.2012.05.005. PMID 23266187. 
• "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics 79 (1): 7–17. January 2002. doi:10.1006/geno.2001.6683. PMID 11827452. https://zenodo.org/record/1229810. 

External links

• Overview of all the structural information available in the PDB for UniProt: Q6NUK1 (Human Calcium-binding mitochondrial carrier protein SCaMC-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.