Biology:Centrin 1
 Generic protein structure example |
Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[1][2] It belongs to the centrin family of proteins.
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[2]
References
- ↑ "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107 ( Pt 1): 9–16. Jun 1994. doi:10.1242/jcs.107.1.9. PMID 8175926.
- ↑ 2.0 2.1 "Entrez Gene: CETN1 centrin, EF-hand protein, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1068.
External links
- Human CETN1 genome location and CETN1 gene details page in the UCSC Genome Browser.
Further reading
- "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.". Mol. Biol. Cell 17 (8): 3423–34. 2006. doi:10.1091/mbc.E06-04-0371. PMID 16760425.
- "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.". Mol. Cell 20 (2): 237–49. 2006. doi:10.1016/j.molcel.2005.08.035. PMID 16246726.
- "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.". Traffic 6 (9): 741–55. 2005. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.". J. Biol. Chem. 276 (23): 20774–80. 2001. doi:10.1074/jbc.M101324200. PMID 11279195.
- "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro.". J. Cell Sci.. 113 ( Pt 8) (8): 1355–64. 2000. doi:10.1242/jcs.113.8.1355. PMID 10725219.
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