Biology:Chromosome 6 open reading frame 203
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Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. [1]
C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.[2][3]
One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.[3] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.[2]
References
- ↑ "Entrez Gene: Chromosome 6 open reading frame 203". https://www.ncbi.nlm.nih.gov/gene/51250.
- ↑ 2.0 2.1 "C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis". Nucleic Acids Research 47 (17): 9386–9399. August 2019. doi:10.1093/nar/gkz684. PMID 31396629.
- ↑ 3.0 3.1 "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria". Nucleic Acids Research 47 (14): 7502–7517. June 2019. doi:10.1093/nar/gkz542. PMID 31226201.
Further reading
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