Biology:Collagen, type XXV, alpha 1
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Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[1][2]
COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][2]
Interactions
Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[1]
References
- ↑ 1.0 1.1 "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J 21 (7): 1524–34. Apr 2002. doi:10.1093/emboj/21.7.1524. PMID 11927537.
- ↑ 2.0 2.1 "Entrez Gene: COL25A1 collagen, type XXV, alpha 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84570.
Further reading
- "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation.". Biochemistry 44 (47): 15602–9. 2006. doi:10.1021/bi051263e. PMID 16300410.
- "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.". FEBS J. 272 (9): 2231–6. 2005. doi:10.1111/j.1742-4658.2005.04647.x. PMID 15853808.
- "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.". J. Biol. Chem. 280 (9): 8596–605. 2005. doi:10.1074/jbc.M413340200. PMID 15615705.
- "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site.". J. Biol. Chem. 280 (2): 1007–15. 2005. doi:10.1074/jbc.M403628200. PMID 15522881.
- "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.". Am. J. Pathol. 165 (1): 273–81. 2004. doi:10.1016/s0002-9440(10)63295-6. PMID 15215182.
- "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.". J. Neuropathol. Exp. Neurol. 62 (11): 1108–17. 2004. doi:10.1093/jnen/62.11.1108. PMID 14656069.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
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