Biology:Cryptotope
From HandWiki
A cryptotope is an antigenic site or epitope hidden in a protein or virion by surface subunits. Cryptotopes are antigenically active only after the dissociation of protein aggregates and virions[1] Some infectious pathogens are known to escape immunological targeting by B-cells by masking antigen-binding sites as cryptotopes.[2] A cryptotope can also be referred to as a cryptic epitope. Cryptotopes are becoming important for HIV vaccine research as a number of studies have shown that cryptic epitopes can be revealed or exposed when HIV gp120 binds to CD4.[3]
References
- ↑ Regenmortel, Marc (2008). "Antigenicity and Immunogenicity of Viral Proteins". Elsevier. http://www.elsevierdirect.com/brochures/Virology/PDFs/00583.pdf.
- ↑ Reider, Franz et al. (22 July 2016). "Microbial Cryptotopes are Prominent Targets of B-cell Immunity". Scientific Reports 6: 31657. doi:10.1038/srep31657. PMID 27539094.
- ↑ Thali, Marcus (July 1993). "Characterization of Conserved Human Immunodeficiency Virus Type 1 gpl20 Neutralization Epitopes Exposed upon gpl20-CD4 Binding". Journal of Virology (American Society for Microbiology) 67 (7): 3978–3988. doi:10.1128/jvi.67.7.3978-3988.1993. PMID 7685405. PMC 237765. http://jvi.asm.org/cgi/reprint/67/7/3978?view=long&pmid=7685405.
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