Biology:DENND1B
From HandWiki
DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1.
Structure
The protein has tripartite DENN domain at N-terminal.
Functions
The protein is a guanine nucleotide exchange factor for RAB35.[1]
Clinical significance
The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma.[2] The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis.[3] Variants of this gene are also associated with obesity in both humans and dogs.[4]
References
- ↑ "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors". Journal of Cell Biology. doi:10.1083/jcb.201008051. https://rupress.org/jcb/article/191/2/367/36173/Family-wide-characterization-of-the-DENN-domain.
- ↑ "Nyt genfund kan skåne børn for astma". http://www.videnskab.dk/composite-3634.htm.
- ↑ "Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT". Clinical Microbiology and Infection 20 (11): O960-8. November 2014. doi:10.1111/1469-0691.12643. PMID 24712925.
- ↑ "Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans". Science. doi:10.1126/science.ads2145. https://www.science.org/doi/10.1126/science.ads2145.
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