Biology:DOK1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.[1][2][3]
Function
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.[4]
Interactions
DOK1 has been shown to interact with:
- ABL1[5][6] and
- CD117,[7]
- INPP5D,[5][8]
- LYN,[5][7]
- RASA1,[6][8][9]
- RET,[10]
- SH2D1A,[11]
- SHC1,[8] and
- TEC.[5][7]
References
- ↑ "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells". Cell 88 (2): 197–204. February 1997. doi:10.1016/S0092-8674(00)81840-1. PMID 9008160.
- ↑ "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia". Genomics 53 (2): 243–5. December 1998. doi:10.1006/geno.1998.5514. PMID 9790776. https://zenodo.org/record/1229765.
- ↑ "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells". J. Biol. Chem. 280 (5): 3151–8. February 2005. doi:10.1074/jbc.M411035200. PMID 15546884.
- ↑ "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1796.
- ↑ 5.0 5.1 5.2 5.3 "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood 96 (10): 3406–13. November 2000. doi:10.1182/blood.V96.10.3406. PMID 11071635. https://pure.eur.nl/en/publications/395fb5fc-60e3-45d7-a9b1-fc7b9cc6b4bc.
- ↑ 6.0 6.1 "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell 88 (2): 205–11. January 1997. doi:10.1016/s0092-8674(00)81841-3. PMID 9008161.
- ↑ 7.0 7.1 7.2 "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. 277 (16): 13732–8. April 2002. doi:10.1074/jbc.M200277200. PMID 11825908.
- ↑ 8.0 8.1 8.2 "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. May 2000. doi:10.1016/s0898-6568(00)00073-5. PMID 10822173.
- ↑ "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. May 2000. doi:10.1074/jbc.275.19.14590. PMID 10799545.
- ↑ "Role of Dok1 in cell signaling mediated by RET tyrosine kinase". J. Biol. Chem. 277 (36): 32781–90. September 2002. doi:10.1074/jbc.M202336200. PMID 12087092.
- ↑ "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. June 2000. doi:10.1073/pnas.130193097. PMID 10852966. Bibcode: 2000PNAS...97.7470S.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations". Leukemia 8 (4): 688–93. 1994. PMID 8152267.
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell 88 (2): 205–11. 1997. doi:10.1016/S0092-8674(00)81841-3. PMID 9008161.
- "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62". J. Exp. Med. 186 (2): 259–67. 1997. doi:10.1084/jem.186.2.259. PMID 9221755.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. 273 (39): 25171–8. 1998. doi:10.1074/jbc.273.39.25171. PMID 9737977.
- "Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration". EMBO J. 18 (7): 1748–60. 1999. doi:10.1093/emboj/18.7.1748. PMID 10202139.
- "Characterization of a novel member of the DOK family that binds and modulates Abl signaling". Mol. Cell. Biol. 19 (12): 8314–25. 1999. doi:10.1128/MCB.19.12.8314. PMID 10567556.
- "SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages". J. Biol. Chem. 274 (50): 35855–65. 1999. doi:10.1074/jbc.274.50.35855. PMID 10585470.
- "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation". Mol. Cell. Biol. 20 (5): 1537–45. 2000. doi:10.1128/MCB.20.5.1537-1545.2000. PMID 10669731.
- "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. 2000. doi:10.1074/jbc.275.19.14590. PMID 10799545.
- "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. 2000. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173.
- "Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1". J. Biol. Chem. 275 (32): 24945–52. 2000. doi:10.1074/jbc.M909012199. PMID 10823839.
- "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. 2000. doi:10.1073/pnas.130193097. PMID 10852966. Bibcode: 2000PNAS...97.7470S.
- "Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del)". Eur. J. Immunogenet. 27 (3): 145–8. 2000. doi:10.1046/j.1365-2370.2000.00203.x. PMID 10940083.
- "Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling". J. Biol. Chem. 276 (4): 2459–65. 2001. doi:10.1074/jbc.M005504200. PMID 11042170. https://authors.library.caltech.edu/9776/1/SONjbc01.pdf.
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