Biology:DPH1
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 Generic protein structure example |
Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene.[1][2][3] It encodes a protein that performs posttranslational modification of histidine-715[4] on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.
References
- ↑ "A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3". Cancer Lett 102 (1–2): 85–90. May 1996. doi:10.1016/0304-3835(96)04169-9. PMID 8603384. https://zenodo.org/record/1258459.
- ↑ "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol 24 (21): 9487–97. Oct 2004. doi:10.1128/MCB.24.21.9487-9497.2004. PMID 15485916.
- ↑ "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1801.
- ↑ "Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development". J. Cell Sci. 121 (Pt 19): 3140–5. 2008. doi:10.1242/jcs.035550. PMID 18765564. "Diphthamide modification is present in all eukaryotic organisms, in which it is restricted to a histidine residue of translation elongation factor 2 (eEF2, also known as EFT1; position 715 in mammals and 699 in yeast)".
Further reading
- "Identification of two candidate tumor suppressor genes on chromosome 17p13.3.". Cancer Res. 56 (9): 1997–2002. 1996. PMID 8616839.
- "Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.". Cancer Res. 59 (19): 4973–83. 1999. PMID 10519411.
- "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor.". Genomics 69 (1): 54–62. 2001. doi:10.1006/geno.2000.6315. PMID 11013075.
- "Cloning, structure, and expression of the mouse Ovca1 gene.". Biochem. Biophys. Res. Commun. 286 (5): 1019–26. 2001. doi:10.1006/bbrc.2001.5488. PMID 11527402.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. 2003. doi:10.1086/374320. PMID 12621583.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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