Biology:DRG2
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Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.[1][2][3]
The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.[3]
References
- ↑ "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet 79 (3–4): 274–5. Jun 1998. doi:10.1159/000134741. PMID 9605870.
- ↑ "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem 269 (41): 25447–53. Nov 1994. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.
- ↑ 3.0 3.1 "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1819.
Further reading
- Sprang SR (1998). "G proteins, effectors and GAPs: structure and mechanism". Curr. Opin. Struct. Biol. 7 (6): 849–56. doi:10.1016/S0959-440X(97)80157-1. PMID 9434906.
- Liang Y; Wang A; Belyantseva IA et al. (2000). "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2". Genomics 61 (3): 243–58. doi:10.1006/geno.1999.5976. PMID 10552926. https://zenodo.org/record/1229792.
- "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta 1491 (1–3): 196–204. 2000. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
- "Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval". Cytogenet. Cell Genet. 88 (3–4): 283–5. 2000. doi:10.1159/000015539. PMID 10828610.
- Bi W; Yan J; Stankiewicz P et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMID 11997338.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Song H; Kim SI; Ko MS et al. (2005). "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis". J. Biochem. 135 (3): 331–5. doi:10.1093/jb/mvh040. PMID 15113831.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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