Biology:Deoxyribonuclease 2 beta
 Generic protein structure example |
Deoxyribonuclease 2 beta is a protein that in humans is encoded by the DNASE2B gene. [1]
Function
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
References
Further reading
- "Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase". Biochem. Biophys. Res. Commun. 288 (5): 1119–28. 2001. doi:10.1006/bbrc.2001.5894. PMID 11700027.
- "Genome-wide association study of alcohol dependence implicates a region on chromosome 11". Alcohol. Clin. Exp. Res. 34 (5): 840–52. 2010. doi:10.1111/j.1530-0277.2010.01156.x. PMID 20201924.
- "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. 2010. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
- "DNase 2 is the main DNA-degrading enzyme of the stratum corneum". PLOS ONE 6 (3): e17581. 2011. doi:10.1371/journal.pone.0017581. PMID 21390259. Bibcode: 2011PLoSO...617581F.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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