Biology:EDF1
 Generic protein structure example |
Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[1][2][3]
Function
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[3]
Interactions
EDF1 has been shown to interact with:
- Liver X receptor alpha,[4]
- Peroxisome proliferator-activated receptor gamma,[4] and
- TATA binding protein.[4][5][6]
References
- ↑ "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem 273 (47): 31119–24. December 1998. doi:10.1074/jbc.273.47.31119. PMID 9813014.
- ↑ "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci 61 (9): 1069–74. April 2004. doi:10.1007/s00018-004-4016-0. PMID 15112053.
- ↑ 3.0 3.1 "Entrez Gene: EDF1 endothelial differentiation-related factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8721.
- ↑ 4.0 4.1 4.2 "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. June 2002. doi:10.1210/mend.16.6.0843. PMID 12040021.
- ↑ "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. August 2000. doi:10.1074/jbc.M001928200. PMID 10816571.
- ↑ "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. November 1999. doi:10.1074/jbc.274.48.34196. PMID 10567391.
Further reading
- "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. 1994. doi:10.1128/mcb.14.5.3013. PMID 8164657.
- "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells 4 (7): 415–24. 1999. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174.
- "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. 2000. doi:10.1074/jbc.M001928200. PMID 10816571.
- "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. 2003. doi:10.1210/mend.16.6.0843. PMID 12040021.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene 374: 87–95. 2006. doi:10.1016/j.gene.2006.01.030. PMID 16567061.
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