Biology:EIF2S3

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.[1][2][3]

Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.[3]

See also

References

  1. "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem 269 (5): 3415–22. Mar 1994. doi:10.1016/S0021-9258(17)41878-3. PMID 8106381. 
  2. "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet 7 (11): 1725–37. Dec 1998. doi:10.1093/hmg/7.11.1725. PMID 9736774. 
  3. 3.0 3.1 "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968. 

Further reading