Biology:EIF2S3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
Generic protein structure example |
Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.[1][2][3]
Function
Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.[3]
See also
References
- ↑ "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem 269 (5): 3415–22. Mar 1994. doi:10.1016/S0021-9258(17)41878-3. PMID 8106381.
- ↑ "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet 7 (11): 1725–37. Dec 1998. doi:10.1093/hmg/7.11.1725. PMID 9736774.
- ↑ 3.0 3.1 "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968.
Further reading
- "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide". Biochemistry 32 (19): 5151–9. 1993. doi:10.1021/bi00070a026. PMID 8098621.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR". J. Biol. Chem. 272 (13): 8388–95. 1997. doi:10.1074/jbc.272.13.8388. PMID 9079663.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms". Arch. Biochem. Biophys. 373 (2): 361–7. 2000. doi:10.1006/abbi.1999.1583. PMID 10620360.
- "Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2". Nucleic Acids Res. 28 (4): 1011–8. 2000. doi:10.1093/nar/28.4.1011. PMID 10648795.
- "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8566–71. 2000. doi:10.1073/pnas.97.15.8566. PMID 10900014. Bibcode: 2000PNAS...97.8566K.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development". Dev. Cell 8 (1): 31–42. 2005. doi:10.1016/j.devcel.2004.10.018. PMID 15669143.
- "Emergence of young human genes after a burst of retroposition in primates". PLOS Biol. 3 (11): e357. 2006. doi:10.1371/journal.pbio.0030357. PMID 16201836.
- "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases". Biochem. Biophys. Res. Commun. 338 (4): 1766–72. 2006. doi:10.1016/j.bbrc.2005.10.150. PMID 16288713.
- "An efficient mammalian cell-free translation system supplemented with translation factors". Protein Expr. Purif. 46 (2): 348–57. 2006. doi:10.1016/j.pep.2005.09.021. PMID 16289705.
- "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics 6 (4): 575–88. 2007. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.