Biology:EIF4A3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

Function

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.

Further reading

• Nagase T; Miyajima N; Tanaka A et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527. 
• Li Q; Imataka H; Morino S et al. (1999). "Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII". Mol. Cell. Biol. 19 (11): 7336–46. doi:10.1128/mcb.19.11.7336. PMID 10523622. 
• Jurica MS; Licklider LJ; Gygi SR et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMID 11991638. 
• Lee S; Baek M; Yang H et al. (2002). "Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays". Cancer Lett. 184 (2): 197–206. doi:10.1016/S0304-3835(02)00197-0. PMID 12127692. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature 427 (6976): 753–7. 2004. doi:10.1038/nature02351. PMID 14973490. 
• Ferraiuolo MA; Lee CS; Ler LW et al. (2004). "A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4118–23. doi:10.1073/pnas.0400933101. PMID 15024115. 
• "eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay". Nat. Struct. Mol. Biol. 11 (4): 346–51. 2004. doi:10.1038/nsmb750. PMID 15034551. 
• Jin J; Smith FD; Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Andersen JS; Lam YW; Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A. 
• Xia Q; Kong XT; Zhang GA et al. (2005). "Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer". Biochem. Biophys. Res. Commun. 330 (2): 526–32. doi:10.1016/j.bbrc.2005.02.181. PMID 15796914. 
• Ballut L; Marchadier B; Baguet A et al. (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity". Nat. Struct. Mol. Biol. 12 (10): 861–9. doi:10.1038/nsmb990. PMID 16170325. 
• Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• Gehring NH; Kunz JB; Neu-Yilik G et al. (2005). "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements". Mol. Cell 20 (1): 65–75. doi:10.1016/j.molcel.2005.08.012. PMID 16209946. 
• Andersen CB; Ballut L; Johansen JS et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA". Science 313 (5795): 1968–72. doi:10.1126/science.1131981. PMID 16931718. 
• You KT; Li LS; Kim NG et al. (2007). "Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors". PLOS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMID 17456004. 
• "Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11574–9. 2007. doi:10.1073/pnas.0704946104. PMID 17606899.