Biology:EIF4EBP2

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.[1][2][3]

Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.[4]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.[1][5]

References

  1. ↑ 1.0 1.1 "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature 371 (6500): 762–7. October 1994. doi:10.1038/371762a0. PMID 7935836. Bibcode: 1994Natur.371..762P. 
  2. ↑ "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics 38 (3): 353–63. December 1996. doi:10.1006/geno.1996.0638. PMID 8975712. 
  3. ↑ "Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1979. 
  4. ↑ "Autism-related deficits via dysregulated eIF4E-dependent translational control". Nature 493 (7432): 371–7. January 2013. doi:10.1038/nature11628. PMID 23172145. Bibcode: 2013Natur.493..371G. 
  5. ↑ "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology 15 (9): 4990–7. September 1995. doi:10.1128/mcb.15.9.4990. PMID 7651417. 

Further reading

  • "Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes". The Journal of Biological Chemistry 271 (47): 30199–204. November 1996. doi:10.1074/jbc.271.47.30199. PMID 8939971. 
  • "4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin". The Journal of Biological Chemistry 277 (16): 13907–17. April 2002. doi:10.1074/jbc.M110782200. PMID 11847216. 
  • "Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1". American Journal of Respiratory Cell and Molecular Biology 27 (2): 250–6. August 2002. doi:10.1165/ajrcmb.27.2.4785. PMID 12151318. 
  • "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". The Journal of Biological Chemistry 278 (48): 47459–65. November 2003. doi:10.1074/jbc.M307949200. PMID 14507920. 
  • "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry 271 (11): 2189–203. June 2004. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109. 
  • "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 





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