Biology:EXTL2
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Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene.[1][2][3] EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)
References
- ↑ "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet 5 (6): 382–9. Mar 1998. doi:10.1159/000484796. PMID 9450183.
- ↑ "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem 280 (25): 23441–5. Jun 2005. doi:10.1074/jbc.M413379200. PMID 15831490.
- ↑ "Entrez Gene: EXTL2 exostoses (multiple)-like 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2135.
Further reading
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. 2000. doi:10.1073/pnas.97.2.668. PMID 10639137. Bibcode: 2000PNAS...97..668M.
- "The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate". J. Biol. Chem. 274 (20): 13933–7. 1999. doi:10.1074/jbc.274.20.13933. PMID 10318803.
- "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. 1998. doi:10.1006/bbrc.1997.8062. PMID 9473480.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2
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