Biology:Eggerthellaceae
The Eggerthellaceae are a family of Gram-positive, rod- or coccus-shaped Actinomycetota.[1] It is the sole family within the order Eggerthellales.[2]
The name Eggerthellaceae is derived from the Latin term Eggerthella, referring to the type genus of the family and the suffix "-ceae," an ending used to denote a family. Together, Eggerthellaceae refers to a family whose nomenclatural type is the genus Eggerthella.[3]
Biochemical characteristics and molecular signatures
Members of this family are mostly anaerobic, non-motile (with the exception of some Gordonibacter and Senegalimassilia species that exhibit motility), asaccharolytic and do not form spores.[3] Eggerthellaceae species are commonly isolated from human and animal faeces and other human sources such as the colon, vagina, oral cavity and blood.[3] Some species have also been isolated from human samples of periodontal or endodontic infections, Crohn's disease and severe blood bacteremia.[3] The G+C content for Eggerthellaceae species is between 43.4 and 66.3 mol%.[3]
Analysis of genome sequences identified 13 conserved signature indels (CSIs) in diverse proteins that are exclusively present in different Eggerthellaceae species. The proteins containing these CSIs are: excinuclease ABC subunit UvrC, DNA polymerase III subunit alpha, ribonuclease III, tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase (MiaB), peptide chain release factor 2, 16S rRNA (cytosine(1402)-N(4))-methyltransferase, elongation factor Tu, UDP-N-acetylglucosamine 1-carboxyvinyltransferase DNA polymerase III subunit epsilon, UDP-glucose 4-epimerase and DNA-directed RNA polymerase subunit alpha.[1][3] The identified CSIs provide reliable and important means to distinguish members of Eggerthellaceae from all other Coriobacteriia as well as other bacteria.
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[2] and National Center for Biotechnology Information (NCBI).[4]
| Nouioui et al. 2018[5][lower-alpha 1] | conserved signature indels by Gupta & Carro 2021[3] | |||||||||||||||||||||||||||||||||||||||||||||||||
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| 16S rRNA based LTP_10_2024[6][7][8] | 120 marker proteins based GTDB 10-RS226[9][10][11] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Genera incertae sedis:
- "Allenteromonas" Liu et al. 2020
- "Mucirhabdus" Liu et al. 2020
- "Stereobacter" Liu et al. 2020
- "Stereobacterium" Liu et al. 2020
- Umbribacter Srinivasan et al. 2025
Notes
- ↑ Asaccharobacter, Ellagibacter, Enteroscipio, Paraeggerthella, and Rubneribacter are not included in this phylogenetic tree.
References
- ↑ 1.0 1.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedGupta - ↑ 2.0 2.1 Eggerthellaceae in LPSN; Freese, H. M.; Meier-Kolthoff, J. P.; Sardà Carbasse, J.; Afolayan, A. O.; Göker, M. (29 October 2025). "TYGS and LPSN in 2025: a Global Core Biodata Resource for genome-based classification and nomenclature of prokaryotes within DSMZ Digital Diversity". Nucleic Acids Research 53: D1–D12. doi:10.1093/nar/gkaf1110.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gupta, Radhey S. (2021), "Eggerthellaceae", in Carro, Lorena (in en), Bergey's Manual of Systematics of Archaea and Bacteria, American Cancer Society, pp. 1–11, doi:10.1002/9781118960608.fbm00384, ISBN 978-1-118-96060-8, https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118960608.fbm00384, retrieved 2021-07-05
- ↑ C.L. Schoch. "Eggerthellaceae". National Center for Biotechnology Information (NCBI) taxonomy database. https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?command=show&mode=tree&id=1643826&lvl=3.
- ↑ "Genome-Based Taxonomic Classification of the Phylum Actinobacteria". Front. Microbiol. 9: 2007. 2018. doi:10.3389/fmicb.2018.02007. PMID 30186281.
- ↑ "The LTP". https://imedea.uib-csic.es/mmg/ltp/#LTP.
- ↑ "LTP_all tree in newick format". https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_all_10_2024.ntree.
- ↑ "LTP_10_2024 Release Notes". https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_10_2024_release_notes.pdf.
- ↑ "GTDB release 10-RS226". https://gtdb.ecogenomic.org/about#4%7C.
- ↑ "bac120_r226.sp_label". https://data.gtdb.ecogenomic.org/releases/release226/226.0/auxillary_files/bac120_r226.sp_labels.tree.
- ↑ "Taxon History". https://gtdb.ecogenomic.org/taxon_history/.
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