Biology:FLT3LG

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.

Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major growth factor stimulating the growth of dendritic cells.

Further reading

• Lyman SD; James L; Vanden Bos T et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells". Cell 75 (6): 1157–67. doi:10.1016/0092-8674(93)90325-K. PMID 7505204. 
• Lyman SD; Stocking K; Davison B et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci". Oncogene 11 (6): 1165–72. PMID 7566977. 
• Lyman SD; James L; Escobar S et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene 10 (1): 149–57. PMID 7824267. 
• Hannum C; Culpepper J; Campbell D et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851. Bibcode: 1994Natur.368..643H. 
• Lyman SD; James L; Johnson L et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". Blood 83 (10): 2795–801. doi:10.1182/blood.V83.10.2795.2795. PMID 8180375. 
• Slanicka Krieger M; Nissen C; Manz CY et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow". Exp. Hematol. 26 (5): 365–73. PMID 9590652. 
• Graddis TJ; Brasel K; Friend D et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen". J. Biol. Chem. 273 (28): 17626–33. doi:10.1074/jbc.273.28.17626. PMID 9651358. 
• Solanilla A; Grosset C; Lemercier C et al. (2000). "Expression of Flt3-ligand by the endothelial cell". Leukemia 14 (1): 153–62. doi:10.1038/sj.leu.2401635. PMID 10637491. 
• Savvides SN; Boone T; Karplus P.A. (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197. 
• Chklovskaia E; Nissen C; Landmann L et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood 97 (4): 1027–34. doi:10.1182/blood.V97.4.1027. PMID 11159533. 
• "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model". Int. Immunopharmacol. 1 (12): 2081–9. 2002. doi:10.1016/S1567-5769(01)00122-9. PMID 11710537. 
• "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi 20 (6): 285–7. 2002. PMID 11721383. 
• Feugier P; Jo DY; Shieh JH et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009. 
• O'Keeffe M; Hochrein H; Vremec D et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice". Blood 99 (6): 2122–30. doi:10.1182/blood.V99.6.2122. PMID 11877288. 
• Retzlaff S; Padró T; Koch P et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma". Oncol. Rep. 9 (3): 525–7. doi:10.3892/or.9.3.525. PMID 11956621. 
• Sigurjónsson OE; Gudmundsson KO; Haraldsdóttir V et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110. 
• Vávrová J; Vokurková D; Mareková M et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells". Folia Biol. (Praha) 48 (2): 51–7. PMID 12002675. 
• Testa U; Torelli GF; Riccioni R et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900. 
• Mosca PJ; Hobeika AC; Colling K et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand". J. Leukoc. Biol. 72 (3): 546–53. doi:10.1189/jlb.72.3.546. PMID 12223523. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.