Biology:FRS3
From HandWiki
 Generic protein structure example |
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.[1][2][3]
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.[3]
References
- ↑ "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene 13 (4): 721–9. Oct 1996. PMID 8761293.
- ↑ "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem 273 (29): 17987–90. Aug 1998. doi:10.1074/jbc.273.29.17987. PMID 9660748.
- ↑ 3.0 3.1 "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10817.
Further reading
- "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.". J. Biol. Chem. 274 (27): 19025–34. 1999. doi:10.1074/jbc.274.27.19025. PMID 10383403.
- "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.". Mol. Cell. Biol. 20 (3): 979–89. 2000. doi:10.1128/MCB.20.3.979-989.2000. PMID 10629055.
- "Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.". J. Biochem. 130 (1): 157–65. 2001. doi:10.1093/oxfordjournals.jbchem.a002955. PMID 11432792.
- "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.". J. Biol. Chem. 277 (19): 17088–94. 2002. doi:10.1074/jbc.M107963200. PMID 11877385.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.". Endocrinology 144 (3): 922–8. 2003. doi:10.1210/en.2002-221002. PMID 12586769.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404.
- "FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.". FEBS Lett. 564 (1–2): 14–8. 2004. doi:10.1016/S0014-5793(04)00287-X. PMID 15094036.
- "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. 2004. doi:10.1002/pmic.200300770. PMID 15188402.
- "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.". Biochem. Biophys. Res. Commun. 324 (3): 1011–7. 2004. doi:10.1016/j.bbrc.2004.09.152. PMID 15485655.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.". J. Biol. Chem. 280 (18): 18418–24. 2005. doi:10.1074/jbc.M411356200. PMID 15738000.
- "Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.". Oncogene 25 (49): 6457–66. 2006. doi:10.1038/sj.onc.1209656. PMID 16702953.
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