Biology:Fellutamide
From HandWiki
Short description: Group of chemical compounds from fungi
Fellutamide A
Fellutamide B
Fellutamides are tripeptide derivatives from Penicillium fellutanum and other fungi. They are potent proteasome inhibitor that stimulates nerve growth factor synthesis in vitro.[1][2]
Fellutamides A and F were first isolated from Aspergillus versicolor.[3][4] Fellutamides C and D were first isolated from an undescribed Metulocladosporiella (Chaetothyriales).[5]
Fellutamide B strongly inhibits the growth of the tuberculosis-causing bacterium Mycobacterium tuberculosis.[6] Its biosynthetic pathway has been determined in the filamentous fungus Aspergillus nidulans.[7]
References
- ↑ "Proteasome inhibition by fellutamide B induces nerve growth factor synthesis". Chemistry & Biology 15 (5): 501–12. May 2008. doi:10.1016/j.chembiol.2008.03.020. PMID 18482702.
- ↑ "Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro". Bioscience, Biotechnology, and Biochemistry 57 (2): 195–9. February 1993. doi:10.1271/bbb.57.195. PMID 7763492.
- ↑ Lee, Yoon-Mi; Dang, Hung The; Hong, Jong-Ki; Lee, Chong-O.; Bae, Kyung-Sook; Kim, Dong-Kyoo; Jung, Jee-H. (2010). "A Cytotoxic Lipopeptide from the Sponge-Derived Fungus Aspergillus versicolor". Bulletin of the Korean Chemical Society 31: 205–208. doi:10.5012/bkcs.2010.31.01.205.
- ↑ Lee, Yoon-Mi; Dang, Hung The; Li, Jianlin; Zhang, Ping; Hong, Jong-Ki; Lee, Chong-O.; Jung, Jee-H. (2011). "A Cytotoxic Fellutamide Analogue from the Sponge-Derived Fungus Aspergillus versicolor". Bulletin of the Korean Chemical Society 32 (10): 3817–3820. doi:10.5012/bkcs.2011.32.10.3817.
- ↑ Xu, Deming; Ondeyka, John; Harris, Guy H.; Zink, Deborah; Kahn, Jennifer Nielsen; Wang, Hao; Bills, Gerald; Platas, Gonzalo et al. (2011). "Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test". Journal of Natural Products 74 (8): 1721–1730. doi:10.1021/np2001573. PMID 21761939.
- ↑ "Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome". Archives of Biochemistry and Biophysics 501 (2): 214–20. September 2010. doi:10.1016/j.abb.2010.06.009. PMID 20558127.
- ↑ "Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor". ACS Chemical Biology 11 (8): 2275–84. August 2016. doi:10.1021/acschembio.6b00213. PMID 27294372.
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