Biology:GGA3
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ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.[1][2]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.[3]
Interactions
GGA3 has been shown to interact with ARF1[1][4] and ARF3.[2][5]
References
- ↑ 1.0 1.1 "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". The Journal of Cell Biology 149 (1): 81–94. April 2000. doi:10.1083/jcb.149.1.81. PMID 10747089.
- ↑ 2.0 2.1 "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell 11 (4): 1241–55. April 2000. doi:10.1091/mbc.11.4.1241. PMID 10749927.
- ↑ "Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23163.
- ↑ "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell 105 (1): 93–102. April 2001. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
- ↑ "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell 13 (9): 3078–95. September 2002. doi:10.1091/mbc.E02-02-0078. PMID 12221117.
Further reading
- "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (4): 167–74, 199-210. August 1995. doi:10.1093/dnares/2.4.167. PMID 8590280.
- "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology 149 (1): 67–80. April 2000. doi:10.1083/jcb.149.1.67. PMID 10747088.
- "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications 271 (3): 719–25. May 2000. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell 105 (1): 93–102. April 2001. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
- "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science 292 (5522): 1712–6. June 2001. doi:10.1126/science.1060750. PMID 11387475. Bibcode: 2001Sci...292.1712P.
- "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature 415 (6874): 933–7. February 2002. doi:10.1038/415933a. PMID 11859375. Bibcode: 2002Natur.415..933M.
- "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". The Biochemical Journal 365 (Pt 2): 369–78. July 2002. doi:10.1042/BJ20020428. PMID 11950392.
- "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology 9 (7): 532–6. July 2002. doi:10.1038/nsb807. PMID 12032548.
- "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proceedings of the National Academy of Sciences of the United States of America 99 (12): 8072–7. June 2002. doi:10.1073/pnas.082235699. PMID 12060753. Bibcode: 2002PNAS...99.8072D.
- "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology 158 (5): 855–62. September 2002. doi:10.1083/jcb.200205078. PMID 12213833.
- "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science 297 (5587): 1700–3. September 2002. doi:10.1126/science.1075327. PMID 12215646. Bibcode: 2002Sci...297.1700D.
- "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell 13 (9): 3078–95. September 2002. doi:10.1091/mbc.E02-02-0078. PMID 12221117.
- "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal 22 (1): 78–88. January 2003. doi:10.1093/emboj/cdg015. PMID 12505986.
- "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications 306 (3): 687–92. July 2003. doi:10.1016/S0006-291X(03)01032-5. PMID 12810073.
- "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry 42 (42): 12174–80. October 2003. doi:10.1021/bi035199h. PMID 14567678.
- "Mammalian GGAs act together to sort mannose 6-phosphate receptors". The Journal of Cell Biology 163 (4): 755–66. November 2003. doi:10.1083/jcb.200308038. PMID 14638859.
- "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". The Journal of Biological Chemistry 279 (8): 7105–11. February 2004. doi:10.1074/jbc.M311702200. PMID 14660606.
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