Biology:GPS1

Generic protein structure example

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. 2004. doi:10.1038/ncb1203-1029. PMID 14647295. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Mol. Cell. Biol. 16 (12): 6698–706. 1997. doi:10.1128/mcb.16.12.6698. PMID 8943324. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. 1998. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. 
• "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. 2001. doi:10.1006/jmbi.2000.4288. PMID 11114242. 
• "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. 2001. doi:10.1093/emboj/20.7.1630. PMID 11285227. 
• "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. 2001. doi:10.1126/science.1059780. PMID 11337588. Bibcode: 2001Sci...292.1382L. 
• "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. 2002. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626. 
• "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. 2003. doi:10.1074/jbc.M208709200. PMID 12324474. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell 15 (3): 719–31. 2003. doi:10.1105/tpc.009092. PMID 12615944. 
• "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. 2003. doi:10.1093/emboj/cdg127. PMID 12628923. 
• "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell 113 (3): 357–67. 2003. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity". FEBS Lett. 572 (1–3): 85–91. 2004. doi:10.1016/j.febslet.2004.07.012. PMID 15304329. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.