Biology:Gasoreceptor
Gasoreceptors are proteins that bind gases such as oxygen (O2), nitric oxide (NO), and ethylene (C2H4), functioning as receptors for these gases in both prokaryotic and eukaryotic cells [1]. They enable cells to directly sense and respond to gaseous molecules, including essential gases like oxygen, which act as signaling molecules as well as substrates for enzymes in metabolic pathways. By detecting the presence and concentration of gases, gasoreceptors trigger appropriate physiological responses. These gasoreceptors can be enzymes, transcription factors, ion channels, and other molecular types.
The identity of oxygen gasoreceptors in mammals and plants are still unknown [2]. Proteins such as androglobin and hemoglobin are proposed as candidate oxygen gasoreceptors due to their enzyme activities [3-5].
Examples:
Oxygen gasoreceptors: E. coli DosP phosphodiesterase, C. elegans GCY-35 soluble guanylate cyclase
Nitric oxide gasoreceptors: H. sapiens GUCY1A3 Soluble guanylate cyclase
Ethylene gasoreceptors: A. thaliana ETR1, ETR2, ERS1, ERS2, EIN4 kinases
References:
1. Anbalagan S. Gas-sensing riboceptors. RNA Biol. 2024. doi: 10.1080/15476286.2024.2379607. PMID 39016047
2. Michael J Holdsworth & Daniel J Gibbs. Comparative Biology of Oxygen Sensing in Plants and Animals. Curr Biol. 2020. doi: 10.1016/j.cub.2020.03.021. PMID: 32315638
3. Anbalagan S. Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors. Animal Model Exp Med. 2024. doi: 10.1002/ame2.12400. PMID: 38529771
4. O V Kosmachevskaya & A F Topunov. Alternate and Additional Functions of Erythrocyte Hemoglobin. Biochemistry (Mosc). 2018. doi: 10.1134/S0006297918120155. PMID: 30878032
5. Anbalagan S. Vertebrate hemoglobin - a dioxygen transporter or proto-gasoreceptor?. Zenodo. 2025. doi: 10.5281/zenodo.16724347
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