Biology:Glypican 4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glypican-4 is a protein that in humans is encoded by the GPC4 gene.[1][2]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.[2]
See also
- Glypican
References
- ↑ "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics 53 (1): 1–11. October 1998. doi:10.1006/geno.1998.5465. PMID 9787072.
- ↑ 2.0 2.1 "Entrez Gene: GPC4 glypican 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2239.
Further reading
- "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae". Journal of Bone and Mineral Research 17 (5): 915–22. May 2002. doi:10.1359/jbmr.2002.17.5.915. PMID 12009023.
- "Cell surface glypicans are low-affinity endostatin receptors". Molecular Cell 7 (4): 811–22. April 2001. doi:10.1016/S1097-2765(01)00225-8. PMID 11336704. https://escholarship.org/content/qt1kx5x9cs/qt1kx5x9cs.pdf?t=oyn3um.
- "Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells". Developmental Dynamics 219 (3): 353–67. November 2000. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-#. PMID 11066092.
- "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene". Human Molecular Genetics 9 (9): 1321–8. May 2000. doi:10.1093/hmg/9.9.1321. PMID 10814714.
- "Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells". The Biochemical Journal. 344 344 Pt 3 (3): 937–43. December 1999. doi:10.1042/bj3440937. PMID 10585884.
- "Glypican 3 and glypican 4 are juxtaposed in Xq26.1". Gene 225 (1–2): 9–16. December 1998. doi:10.1016/S0378-1119(98)00549-6. PMID 9931407. https://zenodo.org/record/1260055.
- "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". The Journal of Cell Biology 130 (5): 1207–18. September 1995. doi:10.1083/jcb.130.5.1207. PMID 7657705.
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