Biology:HCST (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.[1][2]
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[2]
References
- ↑ "An activating immunoreceptor complex formed by NKG2D and DAP10". Science 285 (5428): 730–2. Aug 1999. doi:10.1126/science.285.5428.730. PMID 10426994.
- ↑ 2.0 2.1 "Entrez Gene: HCST hematopoietic cell signal transducer". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10870.
Further reading
- "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.". J. Immunol. 175 (12): 7819–28. 2006. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
- "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.". Eur. J. Immunol. 34 (4): 961–71. 2004. doi:10.1002/eji.200324705. PMID 15048706.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.". Nat. Immunol. 4 (6): 557–64. 2003. doi:10.1038/ni929. PMID 12740575.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.". Nat. Immunol. 3 (12): 1142–9. 2002. doi:10.1038/ni858. PMID 12426565.
- "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. 2002. doi:10.1038/ni857. PMID 12426564. https://zenodo.org/record/1059076.
- "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D.". Immunogenetics 53 (3): 243–9. 2001. doi:10.1007/s002510100321. PMID 11398969.
- "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. 2001. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
- "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.". J. Exp. Med. 192 (7): 1059–68. 2000. doi:10.1084/jem.192.7.1059. PMID 11015446.
- "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.". J. Immunol. 163 (9): 4651–4. 1999. PMID 10528161.
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