Biology:HOTHEAD (gene)
HOTHEAD is an Arabidopsis thaliana gene that encodes a flavin adenine dinucleotide-containing oxidoreductase. This gene has a role in the creation of the carpel during the formation of flowers through the fusion of epidermal cells.[1] Observations of reversion of the hothead phenotype and genotype led to the suggestion that the plants were able to "remember" the sequences of genes present in their ancestors, possibly through a cache of complementary RNA.[2] This report attracted broad attention,[3] and alternative explanations were suggested.[4][5][6] Later research suggested that the supposed reversion phenomenon was due to the plants having a pronounced bias towards outcrossing (because of their floral defects), rather than self-fertilizing at high rates, as is typical for A. thaliana.[7][8][9][10]
References
- ↑ "Isolation and characterization of the Arabidopsis organ fusion gene HOTHEAD". Plant J. 35 (4): 501–11. August 2003. doi:10.1046/j.1365-313x.2003.01824.x. PMID 12904212.
- ↑ "Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis". Nature 434 (7032): 505–9. March 2005. doi:10.1038/nature03380. PMID 15785770. Bibcode: 2005Natur.434..505L.
- ↑ Wade, Nicholas (2005-03-23). "Startling scientists, plant fixes its flawed gene". The New York Times. ISSN 0362-4331. https://www.nytimes.com/2005/03/23/science/startling-scientists-plant-fixes-its-flawed-gene.html. Retrieved 2016-10-24.
- ↑ Chaudhury, A. (2005). "Hothead healer and extragenomic information". Nature 437 (7055): E1–E2. doi:10.1038/nature04062. PMID 16136082. Bibcode: 2005Natur.437E...1C.
- ↑ "A toxic mutator and selection alternative to the non-Mendelian RNA cache hypothesis for hothead reversion". Plant Cell 17 (11): 2856–8. 2005. doi:10.1105/tpc.105.036293. PMID 16267378. summary
- ↑ Krishnaswamy L and Peterson T (2006). "An Alternate Hypothesis to explain the high frequency of "revertants" in Hothead mutants in Arabidopsis". Plant Biology 9 (1): 30–1. doi:10.1055/s-2006-924563. PMID 17048144. https://doi.org/10.1055/s-2006-924563.
- ↑ "Plant genetics: increased outcrossing in hothead mutants". Nature 443 (7110): E8; discussion E8–9. September 2006. doi:10.1038/nature05251. PMID 17006468. Bibcode: 2006Natur.443E...8P.
- ↑ Lolle S. J. (2006). "Increased outcrossing in hothead mutants (Reply)". Nature 443 (7110): E8–E9. doi:10.1038/nature05252. Bibcode: 2006Natur.443E...8L.
- ↑ Science 313 (5795): 1864. 2006. doi:10.1126/science.313.5795.1864. PMID 17008492.
- ↑ "Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants". Genetics 180 (4): 2295–7. December 2008. doi:10.1534/genetics.108.095208. PMID 18845842.
External links and further reading
- Recommendations of 2005 paper on F1000 (most rated paper in the history of the site): http://f1000.com/prime/1024824
- Post by Ogden (2013) describing a follow-up paper: http://blog.f1000research.com/2013/02/04/meddling-with-mendel/
- News piece by Gawrylewski (2008): http://www.the-scientist.com/?articles.view/articleNo/26000/title/Mendel-upended-/
- HOTHEAD locus page: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=30300
 |  |
