Biology:Hepatitis B virus PRE 1151–1410
From HandWiki
| Hepatitis B virus PRE 1151–1410 | |
|---|---|
 Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151–1410 | |
| Identifiers | |
| Rfam | RF02816 |
| Other data | |
| Domain(s) | Viruses |
| GO | 0051168,0043484 |
| SO | 0005836 |
| PDB structures | PDBe |
Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element.[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.[4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.[4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321),[5] human La protein binding site (nucleotide 1275–1291),[6] SRE-1 (nucleotides 1252–1348).[7]
See also
- HBV PRE SL alpha
- HBV PRE SL beta
- HBV RNA encapsidation signal epsilon
References
- ↑ "HBVRegDB: annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences". Virology Journal 4: 136. December 2007. doi:10.1186/1743-422X-4-136. PMID 18086305.
- ↑ "A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products". Molecular and Cellular Biology 13 (12): 7476–7486. December 1993. doi:10.1128/mcb.13.12.7476. PMID 8246965.
- ↑ "Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm". Journal of Virology 68 (5): 3193–3199. May 1994. doi:10.1128/JVI.68.5.3193-3199.1994. PMID 8151782.
- ↑ 4.0 4.1 "A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism". Molecular Biology Reports 42 (12): 1603–1614. December 2015. doi:10.1007/s11033-015-3928-0. PMID 26514143.
- ↑ "Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element". Virology Journal 7: 216. September 2010. doi:10.1186/1743-422X-7-216. PMID 20822550.
- ↑ "Functional characterization of the interaction between human La and hepatitis B virus RNA". The Journal of Biological Chemistry 279 (42): 43437–43447. October 2004. doi:10.1074/jbc.M402227200. PMID 15302879.
- ↑ "The hepatitis B virus PRE contains a splicing regulatory element". Nucleic Acids Research 34 (1): 353–363. 2006. doi:10.1093/nar/gkj440. PMID 16410615.
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