Biology:IGFBP4

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.[1][2][3]

Function

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.[4] IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.

Clinical significance

The protein itself does not prevent the formation of cancer.[5] However it may reduce the growth of cancer and act as an apoptotic factor.

Interactions

IGFBP4 has been shown to interact with Insulin-like growth factor 1 and 2.[6][7]

References

  1. ↑ "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation". Mol Endocrinol 4 (12): 1806–14. May 1991. doi:10.1210/mend-4-12-1806. PMID 1707125. 
  2. ↑ "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human". Mol Endocrinol 4 (10): 1451–8. Mar 1991. doi:10.1210/mend-4-10-1451. PMID 1704481. 
  3. ↑ "Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).". Genomics 49 (3): 401–10. 1998. doi:10.1006/geno.1998.5283. PMID 9615225. 
  4. ↑ "Entrez Gene: IGFBP4 insulin-like growth factor binding protein 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3487. 
  5. ↑ "Role of insulin-like growth factor binding protein-4 in prevention of colon cancer". World J Surg Oncol 5: 128. 2007. doi:10.1186/1477-7819-5-128. PMID 17988381. 
  6. ↑ "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. May 1993. doi:10.1016/S0021-9258(18)98342-0. PMID 7683646. 
  7. ↑ "Structure-function analysis of the human insulin-like growth factor binding protein-4". J. Biol. Chem. 273 (36): 23509–16. Sep 1998. doi:10.1074/jbc.273.36.23509. PMID 9722589. 

Further reading

  • "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. 1998. doi:10.1210/edrv.18.6.0321. PMID 9408744. 
  • "IGF-binding protein-4: biochemical characteristics and functional consequences.". J. Endocrinol. 178 (2): 177–93. 2003. doi:10.1677/joe.0.1780177. PMID 12904166. 
  • "Biology of insulin-like growth factor binding protein-4 and its role in cancer (review).". Int. J. Oncol. 28 (6): 1317–25. 2006. doi:10.3892/ijo.28.6.1317. PMID 16685432. 
  • "Identification of insulin-like growth factor binding proteins in human oviduct.". Fertil. Steril. 57 (2): 294–301. 1992. doi:10.1016/S0015-0282(16)54833-X. PMID 1370941. 
  • "Localization of the human insulin-like growth-factor-binding protein 4 gene to chromosomal region 17q12-21.1.". Hum. Genet. 89 (2): 234–6. 1992. doi:10.1007/BF00217129. PMID 1375185. 
  • "Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.". J. Biol. Chem. 267 (18): 12692–9. 1992. doi:10.1016/S0021-9258(18)42332-0. PMID 1377672. 
  • "Insulin-like growth factor-II and its binding proteins in placental development.". Endocrinology 131 (3): 1230–40. 1992. doi:10.1210/en.131.3.1230. PMID 1380437. 
  • "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.". J. Biol. Chem. 266 (14): 9043–9. 1991. doi:10.1016/S0021-9258(18)31549-7. PMID 1709161. 
  • "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein.". Cancer Res. 51 (11): 2813–9. 1991. PMID 1709585. 
  • "The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer.". Genomics 18 (2): 414–7. 1994. doi:10.1006/geno.1993.1487. PMID 7507078. 
  • "Insulin-like growth factor binding proteins in the human adrenal gland.". Mol. Cell. Endocrinol. 97 (1–2): 71–9. 1994. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
  • "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. 1993. doi:10.1095/biolreprod48.3.467. PMID 7680905. 
  • "Phorbol ester tumor promoters regulate insulin-like growth factor-binding protein-4 proteolysis". Endocrinology 133 (3): 1347–51. 1993. doi:10.1210/endo.133.3.7689953. PMID 7689953. 
  • "Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins". Virology 209 (2): 347–57. 1995. doi:10.1006/viro.1995.1266. PMID 7778269. 
  • "Identification and localization of insulin-like growth factor-binding protein (IGFBP) messenger RNAs in human hair follicle dermal papilla". J. Invest. Dermatol. 106 (3): 471–5. 1996. doi:10.1111/1523-1747.ep12343649. PMID 8648179. 
  • "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • "IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression". Horm. Res. 45 (3–5): 160–6. 1996. doi:10.1159/000184780. PMID 8964576. 
  • "Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes: possible mediation by Ca(++)-calmodulin regulated processes". J. Cell. Biochem. 65 (3): 408–19. 1997. doi:10.1002/(SICI)1097-4644(19970601)65:3<408::AID-JCB10>3.0.CO;2-B. PMID 9138096. 





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