Biology:IGHV@
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Short description: Protein
 Generic protein structure example |
Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.[1][2][3]
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.[4]
See also
References
- ↑ "A deletion map of the human immunoglobulin heavy chain variable region". J Exp Med 174 (2): 335–49. Aug 1991. doi:10.1084/jem.174.2.335. PMID 1649888.
- ↑ Schroeder HW Jr; Walter MA; Hofker MH; Ebens A; Willems van Dijk K; Liao LC; Cox DW; Milner EC et al. (Dec 1988). "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". Proc Natl Acad Sci U S A 85 (21): 8196–200. doi:10.1073/pnas.85.21.8196. PMID 3141924. Bibcode: 1988PNAS...85.8196S.
- ↑ "Entrez Gene: IGHV@ immunoglobulin heavy variable group". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3509.
- ↑ "Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior". Blood 114 (21): 4696–4702. November 2009. doi:10.1182/blood-2009-03-212449. PMID 19667403. http://bloodjournal.hematologylibrary.org/cgi/content/full/114/21/4696.
Further reading
- "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments.". EMBO J. 9 (8): 2501–6. 1990. doi:10.1002/j.1460-2075.1990.tb07429.x. PMID 2114977.
- "New localizations of VH sequences by in situ hybridization with biotinylated probes.". Genes Chromosomes Cancer 2 (2): 103–8. 1991. doi:10.1002/gcc.2870020205. PMID 2126193.
- "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. 1986. doi:10.1073/pnas.82.24.8624. PMID 3866244.
- "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. 1981. doi:10.1073/pnas.77.11.6561. PMID 6450418.
- "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein.". Eur. J. Immunol. 23 (4): 846–51. 1993. doi:10.1002/eji.1830230412. PMID 7681398.
- "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.". Mol. Immunol. 39 (16): 1025–34. 2003. doi:10.1016/S0161-5890(03)00033-6. PMID 12749909.
- "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region.". Int. J. Hematol. 81 (1): 58–61. 2005. doi:10.1532/IJH97.04119. PMID 15717690.
- "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice.". Mol. Immunol. 43 (11): 1827–35. 2006. doi:10.1016/j.molimm.2005.10.015. PMID 16343622.
- "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL).". Hematological Oncology 25 (2): 90–5. 2007. doi:10.1002/hon.812. PMID 17410523.
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