Biology:INTS6
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[1][2][3]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[3]
References
- ↑ "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene 18 (32): 4530–7. Oct 1999. doi:10.1038/sj.onc.1202806. PMID 10467397.
- ↑ "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell 123 (2): 265–76. Oct 2005. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
- ↑ 3.0 3.1 "Entrez Gene: INTS6 integrator complex subunit 6". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=26512.
Further reading
- "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.". Oncogene 26 (35): 5132–44. 2007. doi:10.1038/sj.onc.1210314. PMID 17310990.
- "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions.". Cancer Genet. Cytogenet. 163 (1): 91–2. 2006. doi:10.1016/j.cancergencyto.2005.04.014. PMID 16271964.
- "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer.". Oncogene 24 (44): 6667–75. 2005. doi:10.1038/sj.onc.1208824. PMID 16007164.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Ectopic expression of DICE1 suppresses tumor cell growth.". Oncol. Rep. 12 (2): 207–11. 2005. doi:10.3892/or.12.2.207. PMID 15254679.
- "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma.". Oncogene 22 (2): 314–8. 2003. doi:10.1038/sj.onc.1206098. PMID 12527901.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells.". Oncol. Res. 12 (11–12): 491–500. 2002. doi:10.3727/096504001108747503. PMID 11939413.
- "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12.". Braz. J. Med. Biol. Res. 34 (10): 1237–45. 2002. doi:10.1590/s0100-879x2001001000002. PMID 11593297.
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