Biology:Insulin receptor substrate
From HandWiki
Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells. IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.
Genes
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3P - a pseudogene
- IRS4
References
- "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene 18 (20): 3071–5. 1999. doi:10.1038/sj.onc.1202879. PMID 10340378.
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