Biology:Integrin subunit beta like 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene.

Function

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Further reading

• "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut 58 (8): 1078–83. August 2009. doi:10.1136/gut.2008.169052. PMID 19240061. https://research.vumc.nl/en/publications/9f0b4115-baf6-4bc6-ab6b-4fd7f23f0f0a. 
• "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. November 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. 
• "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care 33 (10): 2250–3. October 2010. doi:10.2337/dc10-0452. PMID 20628086. 
• "ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway". Cancer Res. 75 (16): 3302–13. August 2015. doi:10.1158/0008-5472.CAN-15-0240. PMID 26060017. 
• "Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling". Tumour Biol. 37 (2): 1663–9. February 2016. doi:10.1007/s13277-015-3919-8. PMID 26307393. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.