Biology:KLK15
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.[1][2][3][4][5]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.[5]
References
- ↑ "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". J Biol Chem 276 (1): 53–61. Feb 2001. doi:10.1074/jbc.M005432200. PMID 11010966.
- ↑ "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br J Cancer 87 (11): 1294–300. Nov 2002. doi:10.1038/sj.bjc.6600590. PMID 12439720.
- ↑ "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. Jun 2006. doi:10.1515/BC.2006.082. PMID 16800724. https://epub.ub.uni-muenchen.de/17786/1/bc.2006.082.pdf.
- ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
- ↑ 5.0 5.1 "Entrez Gene: KLK15 kallikrein-related peptidase 15". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55554.
Further reading
- "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. 2001. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891.
- "Human tissue kallikrein gene family: a rich source of novel disease biomarkers". Expert Rev. Mol. Diagn. 1 (2): 182–90. 2002. doi:10.1586/14737159.1.2.182. PMID 11901813.
- "A novel serine proteinase-like sequence from human brain". Biochim. Biophys. Acta 1218 (2): 225–8. 1994. doi:10.1016/0167-4781(94)90018-3. PMID 8018728.
- "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. 2000. doi:10.1006/bbrc.2000.3448. PMID 11006094.
- "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene 257 (1): 119–30. 2001. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
- "Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR". Biochemistry 40 (6): 1679–87. 2001. doi:10.1021/bi002129r. PMID 11327827.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Prognostic value of the human kallikrein gene 15 expression in ovarian cancer". J. Clin. Oncol. 21 (16): 3119–26. 2003. doi:10.1200/JCO.2003.09.111. PMID 12915603.
- "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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