Biology:Keratin 17
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[1][2][3][4]
Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.[4]
Interactions
Keratin 17 has been shown to interact with CCDC85B.[5]
References
- ↑ "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet 9 (3): 273–8. Jul 1995. doi:10.1038/ng0395-273. PMID 7539673.
- ↑ "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol 59 (1): 127–37. Jan 1993. PMID 1281771.
- ↑ "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. Jul 2006. doi:10.1083/jcb.200603161. PMID 16831889.
- ↑ 4.0 4.1 "Entrez Gene: KRT17 keratin 17". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3872.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "Interferon-gamma regulates expression of a novel keratin class I gene". Eur. J. Immunol. 22 (4): 975–9. 1992. doi:10.1002/eji.1830220415. PMID 1372562.
- "Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2319–23. 1990. doi:10.1073/pnas.87.6.2319. PMID 1690428. Bibcode: 1990PNAS...87.2319T.
- "Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes". Nucleic Acids Res. 15 (15): 5945–62. 1987. doi:10.1093/nar/15.15.5945. PMID 2442723.
- "Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin". J. Cell Biol. 127 (2): 505–20. 1994. doi:10.1083/jcb.127.2.505. PMID 7523421.
- "A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21". J. Med. Genet. 31 (9): 675–8. 1995. doi:10.1136/jmg.31.9.675. PMID 7529318.
- "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro". Br. J. Dermatol. 133 (4): 501–11. 1995. doi:10.1111/j.1365-2133.1995.tb02696.x. PMID 7577575.
- "Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex". J. Invest. Dermatol. 108 (2): 220–3. 1997. doi:10.1111/1523-1747.ep12335315. PMID 9008238.
- "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2". Br. J. Dermatol. 139 (3): 475–80. 1999. doi:10.1046/j.1365-2133.1998.02413.x. PMID 9767294.
- "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development". J. Cell Biol. 143 (2): 469–86. 1998. doi:10.1083/jcb.143.2.469. PMID 9786956.
- "Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture". J. Cell Sci. 112 (12): 1925–36. 1999. doi:10.1242/jcs.112.12.1925. PMID 10341211.
- "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2". J. Invest. Dermatol. 113 (5): 848–50. 1999. doi:10.1046/j.1523-1747.1999.00762.x. PMID 10571744.
- "Novel keratin 17 mutations in pachyonychia congenita type 2". J. Invest. Dermatol. 116 (5): 806–8. 2001. doi:10.1046/j.0022-202x.2001.doc.x. PMID 11348474. http://pure.au.dk/portal/da/publications/modulation-of-keratinocyte-gene-expression-and-differentiation-by-pparselective-ligands-and-tetradecylthioacetic-acid(f55fc83d-ccea-4769-8cf4-550e5094f450).html.
- "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. 2001. doi:10.1101/gr.180101. PMID 11591653.
- "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2". J. Invest. Dermatol. 118 (3): 545–7. 2002. doi:10.1046/j.0022-202x.2001.01701.x. PMID 11874497.
- "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita". J. Invest. Dermatol. 117 (6): 1391–6. 2002. doi:10.1046/j.0022-202x.2001.01565.x. PMID 11886499.
- "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". Am. J. Pathol. 161 (6): 1991–6. 2003. doi:10.1016/S0002-9440(10)64476-8. PMID 12466114.
External links
![]() | Original source: https://en.wikipedia.org/wiki/Keratin 17.
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